Drug interactions
Omeprazole + Tecovirimat
Severity: Minor
Omeprazole and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat increases omeprazole exposure substantially. This usually raises acid suppression and is generally tolerable over a short tecovirimat course.
What this interaction means in plain words
Omeprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly inhibits CYP2C19, reducing omeprazole metabolism.
What to do
No routine dose change is needed for the short tecovirimat course; monitor for omeprazole adverse effects such as headache or GI upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Tecovirimat?
MediHelp rates the interaction as minor. Omeprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat increases omeprazole exposure substantially. This usually raises acid suppression and is generally tolerable over a short tecovirimat course.
How serious is the interaction between Omeprazole and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for the short tecovirimat course; monitor for omeprazole adverse effects such as headache or GI upset.
What other medicines interact with Tecovirimat?
MediHelp also lists interactions of Tecovirimat with, for example, Bosentan, Cyclosporin, Darunavir. The full list is on the Tecovirimat page.
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