Drug interactions
Omeprazole + Voriconazole
Severity: Moderate
Omeprazole and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C19 and CYP3A4, substantially raising omeprazole exposure, while omeprazole may in turn raise voriconazole levels. Labeling advises halving the omeprazole dose when 40 mg or more is used.
What this interaction means in plain words
Omeprazole and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Mutual inhibition of CYP2C19 and CYP3A4 metabolism.
What to do
Reduce omeprazole dose by half if the dose is 40 mg or more daily. Monitor for voriconazole toxicity and efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Omeprazole with Voriconazole?
MediHelp rates the interaction as moderate. Omeprazole and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C19 and CYP3A4, substantially raising omeprazole exposure, while omeprazole may in turn raise voriconazole levels. Labeling advises halving the omeprazole dose when 40 mg or more is used.
How serious is the interaction between Omeprazole and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce omeprazole dose by half if the dose is 40 mg or more daily. Monitor for voriconazole toxicity and efficacy.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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