Drug interactions
Ondansetron + Quizartinib
Severity: Major
Ondansetron and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and quizartinib carries a boxed warning for QT prolongation, torsades de pointes and cardiac arrest. Giving ondansetron with it can add to the risk of serious ventricular arrhythmia, particularly if electrolytes are abnormal.
What this interaction means in plain words
Ondansetron and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ondansetron belongs to Gastrointestinal Tract; Quizartinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through delayed cardiac repolarization (hERG potassium channel effects).
What to do
Avoid the combination if possible and choose a non-QT-prolonging antiemetic. If it is unavoidable, correct potassium and magnesium and monitor ECG more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Ondansetron with Quizartinib?
MediHelp rates the interaction as major. Ondansetron and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and quizartinib carries a boxed warning for QT prolongation, torsades de pointes and cardiac arrest. Giving ondansetron with it can add to the risk of serious ventricular arrhythmia, particularly if electrolytes are abnormal.
How serious is the interaction between Ondansetron and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose a non-QT-prolonging antiemetic. If it is unavoidable, correct potassium and magnesium and monitor ECG more frequently.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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