Drug interactions
Ondansetron + Sarecycline
Severity: Minor
Ondansetron and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is reported to inhibit P-glycoprotein, which could slightly raise ondansetron exposure. Clinical relevance is likely small.
What this interaction means in plain words
Ondansetron and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline increases ondansetron absorption or reduces efflux.
What to do
No dose adjustment is routinely needed. Monitor for ondansetron adverse effects such as headache and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Ondansetron with Sarecycline?
MediHelp rates the interaction as minor. Ondansetron and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is reported to inhibit P-glycoprotein, which could slightly raise ondansetron exposure. Clinical relevance is likely small.
How serious is the interaction between Ondansetron and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for ondansetron adverse effects such as headache and constipation.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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