Drug interactions
Ondansetron + Sumatriptan
Severity: Minor
Ondansetron and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to serotonin syndrome in isolated reports when combined with serotonergic agents. The risk with this pair is low, and they are commonly used together for migraine with nausea.
What this interaction means in plain words
Ondansetron and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Sumatriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effects; the mechanism is not well established.
What to do
Combined use is usually acceptable; advise patients to report agitation, tremor, sweating or fever. Stop the drugs if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Ondansetron with Sumatriptan?
MediHelp rates the interaction as minor. Ondansetron and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been linked to serotonin syndrome in isolated reports when combined with serotonergic agents. The risk with this pair is low, and they are commonly used together for migraine with nausea.
How serious is the interaction between Ondansetron and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combined use is usually acceptable; advise patients to report agitation, tremor, sweating or fever. Stop the drugs if serotonin toxicity is suspected.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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