Drug interactions
Ondansetron + Umeclidinium-vilanterol
Severity: Moderate
Ondansetron and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron causes dose-dependent QT prolongation, particularly with intravenous dosing. Vilanterol may add to arrhythmic risk via adrenergic stimulation and hypokalemia.
What this interaction means in plain words
Ondansetron and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist-related hypokalemia.
What to do
Correct electrolyte abnormalities and use the lowest effective ondansetron dose. Monitor the ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ondansetron and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron causes dose-dependent QT prolongation, particularly with intravenous dosing. Vilanterol may add to arrhythmic risk via adrenergic stimulation and hypokalemia.
How serious is the interaction between Ondansetron and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte abnormalities and use the lowest effective ondansetron dose. Monitor the ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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