Drug interactions
Ondansetron + Voxelotor
Severity: Minor
Ondansetron and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Ondansetron is cleared by multiple pathways, so any rise in levels is likely modest.
What this interaction means in plain words
Ondansetron and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibition of CYP3A4 may modestly reduce ondansetron clearance.
What to do
No routine dose adjustment is required. Monitor for ondansetron adverse effects such as constipation, headache and QT changes in patients at cardiac risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Ondansetron with Voxelotor?
MediHelp rates the interaction as minor. Ondansetron and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Ondansetron is cleared by multiple pathways, so any rise in levels is likely modest.
How serious is the interaction between Ondansetron and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required. Monitor for ondansetron adverse effects such as constipation, headache and QT changes in patients at cardiac risk.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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