Drug interactions
Orlistat + Perampanel
Severity: Moderate
Orlistat and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat could reduce absorption of lipophilic drugs, and reduced antiseizure drug levels have been described with other agents. Data for perampanel are lacking, but a fall in levels could risk breakthrough seizures.
What this interaction means in plain words
Orlistat and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Perampanel belongs to Central Nervous System.
Why it happens
Possible reduced gastrointestinal absorption of perampanel through lipase inhibition and altered fat handling; not well characterized.
What to do
Monitor seizure control if orlistat is started or stopped. Consider taking perampanel at bedtime, well apart from orlistat meals, and review clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Orlistat and Perampanel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Orlistat with Perampanel?
MediHelp rates the interaction as moderate. Orlistat and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat could reduce absorption of lipophilic drugs, and reduced antiseizure drug levels have been described with other agents. Data for perampanel are lacking, but a fall in levels could risk breakthrough seizures.
How serious is the interaction between Orlistat and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control if orlistat is started or stopped. Consider taking perampanel at bedtime, well apart from orlistat meals, and review clinical response.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
