Drug interactions
Orphenadrin + Oxycodone
Severity: Major
Orphenadrin and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine may increase the sedation and respiratory depression of oxycodone, and adds anticholinergic effects such as constipation and urinary retention. Risk is highest at initiation and with dose increases.
What this interaction means in plain words
Orphenadrin and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Orphenadrin belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression, with added anticholinergic effects.
What to do
Avoid if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Orphenadrin with Oxycodone?
MediHelp rates the interaction as major. Orphenadrin and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine may increase the sedation and respiratory depression of oxycodone, and adds anticholinergic effects such as constipation and urinary retention. Risk is highest at initiation and with dose increases.
How serious is the interaction between Orphenadrin and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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