Drug interactions
Orphenadrin + Stiripentol
Severity: Moderate
Orphenadrin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence, and orphenadrine adds to CNS depression. Stiripentol also inhibits several CYP enzymes, which could raise orphenadrine levels.
What this interaction means in plain words
Orphenadrin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression; possible CYP inhibition by stiripentol increasing orphenadrine exposure.
What to do
Monitor for excessive sedation and anticholinergic effects, and reduce the orphenadrine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Stiripentol
Frequently asked questions
Can I take Orphenadrin with Stiripentol?
MediHelp rates the interaction as moderate. Orphenadrin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence, and orphenadrine adds to CNS depression. Stiripentol also inhibits several CYP enzymes, which could raise orphenadrine levels.
How serious is the interaction between Orphenadrin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and anticholinergic effects, and reduce the orphenadrine dose if needed.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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