Drug interactions
Orphenadrin + Trazodone
Severity: Moderate
Orphenadrin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is sedating and has mild anticholinergic activity, which adds to orphenadrine's effects. Combined use may increase drowsiness, dizziness and dry mouth, with a higher risk of falls in older adults.
What this interaction means in plain words
Orphenadrin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Start with low doses and monitor sedation and anticholinergic symptoms. Advise caution with driving and take fall precautions in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Orphenadrin with Trazodone?
MediHelp rates the interaction as moderate. Orphenadrin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is sedating and has mild anticholinergic activity, which adds to orphenadrine's effects. Combined use may increase drowsiness, dizziness and dry mouth, with a higher risk of falls in older adults.
How serious is the interaction between Orphenadrin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation and anticholinergic symptoms. Advise caution with driving and take fall precautions in older patients.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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