Drug interactions
Osilodrostat + Oxaliplatin
Severity: Moderate
Osilodrostat and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are labeled with QT interval prolongation risk. Combined use may increase the chance of QT prolongation and torsades de pointes, especially with electrolyte disturbances such as hypokalemia, which oxaliplatin-related diarrhea or vomiting can cause.
What this interaction means in plain words
Osilodrostat and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium before and during therapy. Avoid adding other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Oxaliplatin?
MediHelp rates the interaction as moderate. Osilodrostat and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are labeled with QT interval prolongation risk. Combined use may increase the chance of QT prolongation and torsades de pointes, especially with electrolyte disturbances such as hypokalemia, which oxaliplatin-related diarrhea or vomiting can cause.
How serious is the interaction between Osilodrostat and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium before and during therapy. Avoid adding other QT-prolonging drugs where possible.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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