Drug interactions
Osilodrostat + Paliperidone
Severity: Major
Osilodrostat and Paliperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so the combination may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to this risk.
What this interaction means in plain words
Osilodrostat and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with osilodrostat-related hypokalemia as an additional contributor.
What to do
Obtain a baseline ECG and repeat after initiation or dose changes, and correct potassium and magnesium before and during treatment. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Paliperidone?
MediHelp rates the interaction as major. Osilodrostat and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so the combination may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to this risk.
How serious is the interaction between Osilodrostat and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after initiation or dose changes, and correct potassium and magnesium before and during treatment. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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