Drug interactions
Osilodrostat + Ribociclib
Severity: Major
Osilodrostat and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval in a dose-dependent manner. Combined use raises the risk of torsades de pointes, particularly with hypokalemia or hypomagnesemia.
What this interaction means in plain words
Osilodrostat and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Avoid if possible. If used together, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Ribociclib?
MediHelp rates the interaction as major. Osilodrostat and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval in a dose-dependent manner. Combined use raises the risk of torsades de pointes, particularly with hypokalemia or hypomagnesemia.
How serious is the interaction between Osilodrostat and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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