Drug interactions
Osilodrostat + Solifenacin
Severity: Moderate
Osilodrostat and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Osilodrostat and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor ECG and serum potassium and magnesium during treatment, correcting abnormalities before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Solifenacin?
MediHelp rates the interaction as moderate. Osilodrostat and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Osilodrostat and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and serum potassium and magnesium during treatment, correcting abnormalities before starting.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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