Drug interactions
Osimertinib + Perphenazine
Severity: Moderate
Osimertinib and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval, and perphenazine has a recognized potential for QT prolongation. Using both increases the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Osimertinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain periodic ECGs and monitor potassium, magnesium and calcium. Consider an alternative antipsychotic or stop osimertinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Perphenazine?
MediHelp rates the interaction as moderate. Osimertinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval, and perphenazine has a recognized potential for QT prolongation. Using both increases the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Osimertinib and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain periodic ECGs and monitor potassium, magnesium and calcium. Consider an alternative antipsychotic or stop osimertinib if the QTc becomes markedly prolonged.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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