Drug interactions
Osimertinib + Rosuvastatin
Severity: Moderate
Osimertinib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib inhibits BCRP and can raise rosuvastatin exposure, a BCRP substrate, by a modest amount. This may increase the risk of statin-related muscle toxicity, though the effect is generally small.
What this interaction means in plain words
Osimertinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Osimertinib inhibits the efflux transporter BCRP, reducing rosuvastatin efflux and increasing its systemic exposure.
What to do
Monitor for myalgia, weakness or dark urine, and check CK if symptoms occur. Reduce the rosuvastatin dose if muscle toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osimertinib
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Osimertinib with Rosuvastatin?
MediHelp rates the interaction as moderate. Osimertinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib inhibits BCRP and can raise rosuvastatin exposure, a BCRP substrate, by a modest amount. This may increase the risk of statin-related muscle toxicity, though the effect is generally small.
How serious is the interaction between Osimertinib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia, weakness or dark urine, and check CK if symptoms occur. Reduce the rosuvastatin dose if muscle toxicity develops.
What other medicines interact with Osimertinib?
MediHelp also lists interactions of Osimertinib with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Osimertinib page.
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