Drug interactions
Osimertinib + Solifenacin
Severity: Moderate
Osimertinib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lengthen the QT interval, so the combination may increase the risk of serious ventricular arrhythmia, especially with electrolyte disorders or other QT-prolonging drugs.
What this interaction means in plain words
Osimertinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform periodic ECG monitoring and check electrolytes, correcting potassium and magnesium; consider an alternative to solifenacin in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Solifenacin?
MediHelp rates the interaction as moderate. Osimertinib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lengthen the QT interval, so the combination may increase the risk of serious ventricular arrhythmia, especially with electrolyte disorders or other QT-prolonging drugs.
How serious is the interaction between Osimertinib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check electrolytes, correcting potassium and magnesium; consider an alternative to solifenacin in patients with QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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