Drug interactions
Osimertinib + Tacrolimus
Severity: Moderate
Osimertinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias. Risk is higher with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Osimertinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes periodically and correct potassium and magnesium abnormalities. Withhold or reduce osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Tacrolimus?
MediHelp rates the interaction as moderate. Osimertinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias. Risk is higher with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Osimertinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct potassium and magnesium abnormalities. Withhold or reduce osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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