Drug interactions
Ospemifene + Ribociclib
Severity: Moderate
Ospemifene and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is metabolized by CYP3A4 and CYP2C9, and CYP3A4 inhibitors raise its exposure. Ribociclib may therefore increase ospemifene levels, and ospemifene has an estrogen agonist effect on the endometrium and carries thromboembolic warnings. It is also not suited to patients with breast cancer.
What this interaction means in plain words
Ospemifene and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ospemifene belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ospemifene metabolism by ribociclib.
What to do
Avoid ospemifene in patients with breast cancer; if it is considered, use an alternative for vulvovaginal atrophy and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ospemifene and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Ospemifene with Ribociclib?
MediHelp rates the interaction as moderate. Ospemifene and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is metabolized by CYP3A4 and CYP2C9, and CYP3A4 inhibitors raise its exposure. Ribociclib may therefore increase ospemifene levels, and ospemifene has an estrogen agonist effect on the endometrium and carries thromboembolic warnings. It is also not suited to patients with breast cancer.
How serious is the interaction between Ospemifene and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ospemifene in patients with breast cancer; if it is considered, use an alternative for vulvovaginal atrophy and monitor for adverse effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
