Drug interactions
Oteseconazole + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Oteseconazole and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and may increase exposure to sofosbuvir and voxilaprevir, both of which are BCRP substrates. The increase is expected to be modest and is unlikely to be clinically significant in most patients.
What this interaction means in plain words
Oteseconazole and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oteseconazole belongs to Anti Fungals; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Oteseconazole inhibits intestinal BCRP efflux, which may increase absorption of BCRP substrates such as sofosbuvir and voxilaprevir.
What to do
No empirical dose change is required. Monitor for adverse effects of the antiviral combination and liver function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Oteseconazole with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Oteseconazole and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP and may increase exposure to sofosbuvir and voxilaprevir, both of which are BCRP substrates. The increase is expected to be modest and is unlikely to be clinically significant in most patients.
How serious is the interaction between Oteseconazole and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor for adverse effects of the antiviral combination and liver function.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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