Drug interactions
Oxaliplatin + Selinexor
Severity: Moderate
Oxaliplatin and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes nausea, vomiting, diarrhea, fatigue and dizziness, and oxaliplatin causes similar gastrointestinal effects and neurotoxicity. Combined use may worsen dehydration, electrolyte loss and neurological symptoms.
What this interaction means in plain words
Oxaliplatin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
Overlapping adverse effects (gastrointestinal and neurological toxicity); no specific pharmacokinetic mechanism is established.
What to do
Give prophylactic antiemetics and monitor hydration, sodium and neurological status. Reduce or interrupt doses for significant toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Oxaliplatin with Selinexor?
MediHelp rates the interaction as moderate. Oxaliplatin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes nausea, vomiting, diarrhea, fatigue and dizziness, and oxaliplatin causes similar gastrointestinal effects and neurotoxicity. Combined use may worsen dehydration, electrolyte loss and neurological symptoms.
How serious is the interaction between Oxaliplatin and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give prophylactic antiemetics and monitor hydration, sodium and neurological status. Reduce or interrupt doses for significant toxicity.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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