Drug interactions
Oxaliplatin + Solifenacin
Severity: Moderate
Oxaliplatin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and torsades, and solifenacin has a small QT effect. Combined use may increase arrhythmia risk, especially with chemotherapy-related electrolyte loss.
What this interaction means in plain words
Oxaliplatin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor electrolytes and the ECG during oxaliplatin treatment, and correct hypokalemia and hypomagnesemia. Choose another bladder therapy if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Solifenacin?
MediHelp rates the interaction as moderate. Oxaliplatin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and torsades, and solifenacin has a small QT effect. Combined use may increase arrhythmia risk, especially with chemotherapy-related electrolyte loss.
How serious is the interaction between Oxaliplatin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes and the ECG during oxaliplatin treatment, and correct hypokalemia and hypomagnesemia. Choose another bladder therapy if the QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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