Drug interactions
Oxaliplatin + Tacrolimus
Severity: Major
Oxaliplatin and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is an immunosuppressant that can prolong the QT interval, and oxaliplatin is myelosuppressive and may also affect the QT interval. Together they increase infection risk and may add to arrhythmia risk. Tacrolimus nephrotoxicity may also affect clearance of platinum-related toxicity.
What this interaction means in plain words
Oxaliplatin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression and myelosuppression, plus additive QT prolongation.
What to do
Monitor blood counts, renal function, tacrolimus trough levels and ECG. Reassess the need for immunosuppression and adjust the dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tacrolimus?
MediHelp rates the interaction as major. Oxaliplatin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tacrolimus is an immunosuppressant that can prolong the QT interval, and oxaliplatin is myelosuppressive and may also affect the QT interval. Together they increase infection risk and may add to arrhythmia risk. Tacrolimus nephrotoxicity may also affect clearance of platinum-related toxicity.
How serious is the interaction between Oxaliplatin and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal function, tacrolimus trough levels and ECG. Reassess the need for immunosuppression and adjust the dose as needed.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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