Drug interactions
Oxaliplatin + Vemurafenib
Severity: Major
Oxaliplatin and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval, and oxaliplatin has also been linked to QT prolongation. Combined use may add to the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Oxaliplatin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform ECG and electrolyte checks at baseline and periodically during therapy. Interrupt or reduce vemurafenib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Oxaliplatin with Vemurafenib?
MediHelp rates the interaction as major. Oxaliplatin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval, and oxaliplatin has also been linked to QT prolongation. Combined use may add to the risk of serious ventricular arrhythmias.
How serious is the interaction between Oxaliplatin and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG and electrolyte checks at baseline and periodically during therapy. Interrupt or reduce vemurafenib if QTc becomes significantly prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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