Drug interactions
Oxaprozin + Paromomycin
Severity: Minor
Oxaprozin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may slow aminoglycoside clearance, an effect described mainly in preterm infants. Oral paromomycin is minimally absorbed, so a meaningful systemic interaction is unlikely.
What this interaction means in plain words
Oxaprozin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxaprozin belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal perfusion could reduce elimination of any absorbed aminoglycoside.
What to do
No action needed in most patients; monitor renal function if paromomycin is used with severe bowel inflammation or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Oxaprozin with Paromomycin?
MediHelp rates the interaction as minor. Oxaprozin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may slow aminoglycoside clearance, an effect described mainly in preterm infants. Oral paromomycin is minimally absorbed, so a meaningful systemic interaction is unlikely.
How serious is the interaction between Oxaprozin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed in most patients; monitor renal function if paromomycin is used with severe bowel inflammation or renal impairment.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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