Drug interactions
Oxaprozin + Vadadustat
Severity: Moderate
Oxaprozin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may inhibit the renal transporters OAT1 and OAT3, which could increase vadadustat exposure. Higher exposure may cause an excessive or rapid rise in hemoglobin and more adverse effects.
What this interaction means in plain words
Oxaprozin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated renal transport reduces vadadustat clearance.
What to do
Monitor hemoglobin closely after starting or stopping oxaprozin and adjust the vadadustat dose according to labeling. Watch for hypertension and thromboembolic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Oxaprozin with Vadadustat?
MediHelp rates the interaction as moderate. Oxaprozin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may inhibit the renal transporters OAT1 and OAT3, which could increase vadadustat exposure. Higher exposure may cause an excessive or rapid rise in hemoglobin and more adverse effects.
How serious is the interaction between Oxaprozin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely after starting or stopping oxaprozin and adjust the vadadustat dose according to labeling. Watch for hypertension and thromboembolic events.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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