Drug interactions
Oxazepam + Perampanel
Severity: Moderate
Oxazepam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause dizziness, somnolence and impaired coordination, and these effects may add to those of oxazepam. Perampanel labeling also warns of psychiatric and behavioral effects, which sedatives may complicate.
What this interaction means in plain words
Oxazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression from AMPA receptor antagonism by perampanel and GABA-A potentiation by oxazepam.
What to do
Monitor for sedation, ataxia, falls and mood or behavioral changes, particularly during perampanel titration. Counsel against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxazepam and Perampanel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Oxazepam with Perampanel?
MediHelp rates the interaction as moderate. Oxazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause dizziness, somnolence and impaired coordination, and these effects may add to those of oxazepam. Perampanel labeling also warns of psychiatric and behavioral effects, which sedatives may complicate.
How serious is the interaction between Oxazepam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia, falls and mood or behavioral changes, particularly during perampanel titration. Counsel against driving until tolerance is established.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
