Drug interactions
Oxcarbazepine + Pacritinib
Severity: Moderate
Oxcarbazepine and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may lower pacritinib exposure. Reduced pacritinib levels could lead to loss of efficacy in myelofibrosis. Pacritinib labeling advises avoiding strong CYP3A4 inducers, and the effect of oxcarbazepine is expected to be smaller.
What this interaction means in plain words
Oxcarbazepine and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Oxcarbazepine and its metabolite induce CYP3A4, increasing the metabolism of pacritinib.
What to do
Monitor spleen and symptom response to pacritinib, and consider an alternative anticonvulsant without CYP3A4 induction if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Oxcarbazepine with Pacritinib?
MediHelp rates the interaction as moderate. Oxcarbazepine and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may lower pacritinib exposure. Reduced pacritinib levels could lead to loss of efficacy in myelofibrosis. Pacritinib labeling advises avoiding strong CYP3A4 inducers, and the effect of oxcarbazepine is expected to be smaller.
How serious is the interaction between Oxcarbazepine and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen and symptom response to pacritinib, and consider an alternative anticonvulsant without CYP3A4 induction if response declines.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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