Drug interactions
Oxcarbazepine + Tasimelteon
Severity: Moderate
Oxcarbazepine and Tasimelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower tasimelteon exposure, possibly reducing its efficacy for non-24-hour sleep-wake disorder.
What this interaction means in plain words
Oxcarbazepine and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases tasimelteon metabolism.
What to do
Monitor clinical response to tasimelteon. Consider an alternative anticonvulsant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Oxcarbazepine with Tasimelteon?
MediHelp rates the interaction as moderate. Oxcarbazepine and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower tasimelteon exposure, possibly reducing its efficacy for non-24-hour sleep-wake disorder.
How serious is the interaction between Oxcarbazepine and Tasimelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tasimelteon. Consider an alternative anticonvulsant.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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