Drug interactions
Oxcarbazepine + Ubrogepant
Severity: Moderate
Oxcarbazepine and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce ubrogepant exposure and reduce its efficacy in acute migraine. Labeling recommends dose adjustment with CYP3A4 inducers.
What this interaction means in plain words
Oxcarbazepine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Ubrogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction by oxcarbazepine increases ubrogepant metabolism.
What to do
Use the labeled higher single dose of ubrogepant for moderate inducers and monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Oxcarbazepine with Ubrogepant?
MediHelp rates the interaction as moderate. Oxcarbazepine and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce ubrogepant exposure and reduce its efficacy in acute migraine. Labeling recommends dose adjustment with CYP3A4 inducers.
How serious is the interaction between Oxcarbazepine and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled higher single dose of ubrogepant for moderate inducers and monitor migraine response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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