Drug interactions
Oxybutynin + Prochlorperazine
Severity: Moderate
Oxybutynin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially vulnerable to cognitive effects and heat intolerance.
What this interaction means in plain words
Oxybutynin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects; anticholinergics may also slow gastric motility and modestly alter oral phenothiazine absorption.
What to do
Monitor for anticholinergic toxicity and cognitive changes, especially in older adults. Consider an alternative antiemetic or bladder agent with less anticholinergic burden if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Oxybutynin
Frequently asked questions
Can I take Oxybutynin with Prochlorperazine?
MediHelp rates the interaction as moderate. Oxybutynin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially vulnerable to cognitive effects and heat intolerance.
How serious is the interaction between Oxybutynin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive changes, especially in older adults. Consider an alternative antiemetic or bladder agent with less anticholinergic burden if symptoms develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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