Drug interactions
Oxycodone + Pancuronium
Severity: Moderate
Oxycodone and Pancuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone may add to the effects of pancuronium, prolonging muscle weakness and respiratory depression. This is mainly relevant during anesthesia and intensive care.
What this interaction means in plain words
Oxycodone and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from opioid central effects; a direct effect on neuromuscular transmission is not well established.
What to do
Monitor neuromuscular function and ventilation and titrate the blocker to response. Ensure ventilatory support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Pancuronium
Frequently asked questions
Can I take Oxycodone with Pancuronium?
MediHelp rates the interaction as moderate. Oxycodone and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxycodone may add to the effects of pancuronium, prolonging muscle weakness and respiratory depression. This is mainly relevant during anesthesia and intensive care.
How serious is the interaction between Oxycodone and Pancuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function and ventilation and titrate the blocker to response. Ensure ventilatory support is available.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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