Drug interactions
Oxycodone + Prasugrel
Severity: Moderate
Oxycodone and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids delay and reduce the absorption of oral P2Y12 inhibitors, including prasugrel, which may lower early platelet inhibition. This matters most in acute coronary syndromes and around PCI.
What this interaction means in plain words
Oxycodone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced delayed gastric emptying reduces the rate and extent of prasugrel active metabolite exposure.
What to do
In acute coronary syndrome, consider a parenteral antiplatelet agent if opioids are needed. Use the lowest effective opioid dose and non-opioid analgesia where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Prasugrel
Frequently asked questions
Can I take Oxycodone with Prasugrel?
MediHelp rates the interaction as moderate. Oxycodone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids delay and reduce the absorption of oral P2Y12 inhibitors, including prasugrel, which may lower early platelet inhibition. This matters most in acute coronary syndromes and around PCI.
How serious is the interaction between Oxycodone and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome, consider a parenteral antiplatelet agent if opioids are needed. Use the lowest effective opioid dose and non-opioid analgesia where possible.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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