Drug interactions
Oxycodone + Procarbazine
Severity: Major
Oxycodone and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting properties and may cause serotonin syndrome or exaggerated opioid CNS depression and hypotension with oxycodone.
What this interaction means in plain words
Oxycodone and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxycodone belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine combined with opioid serotonergic and CNS depressant effects.
What to do
Avoid concurrent use where possible; use the lowest oxycodone dose with close monitoring for serotonin toxicity, hypotension and sedation if essential.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Oxycodone with Procarbazine?
MediHelp rates the interaction as major. Oxycodone and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has MAO-inhibiting properties and may cause serotonin syndrome or exaggerated opioid CNS depression and hypotension with oxycodone.
How serious is the interaction between Oxycodone and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; use the lowest oxycodone dose with close monitoring for serotonin toxicity, hypotension and sedation if essential.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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