Drug interactions
Oxycodone + Propafenone
Severity: Minor
Oxycodone and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a CYP2D6 inhibitor and may reduce conversion of oxycodone to oxymorphone. The effect on analgesia and adverse effects is variable and usually modest because oxycodone itself is the main active moiety.
What this interaction means in plain words
Oxycodone and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxycodone belongs to Musculoskeletal; Propafenone belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated oxycodone O-demethylation by propafenone, with possible shunting toward CYP3A4 metabolism.
What to do
Titrate oxycodone to clinical response and watch for reduced analgesia or increased sedation. Adjust the dose if the response changes after propafenone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Oxycodone with Propafenone?
MediHelp rates the interaction as minor. Oxycodone and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone is a CYP2D6 inhibitor and may reduce conversion of oxycodone to oxymorphone. The effect on analgesia and adverse effects is variable and usually modest because oxycodone itself is the main active moiety.
How serious is the interaction between Oxycodone and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oxycodone to clinical response and watch for reduced analgesia or increased sedation. Adjust the dose if the response changes after propafenone is started or stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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