Drug interactions
Oxycodone + Quinidine
Severity: Moderate
Oxycodone and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP2D6 and CYP3A4, which can reduce oxymorphone formation and raise oxycodone levels. Analgesia may change and opioid adverse effects may increase.
What this interaction means in plain words
Oxycodone and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibition of CYP2D6 and CYP3A4 alters oxycodone metabolism.
What to do
Monitor pain control and signs of opioid excess, titrating oxycodone to effect. Reduce the dose if sedation or respiratory depression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Oxycodone with Quinidine?
MediHelp rates the interaction as moderate. Oxycodone and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP2D6 and CYP3A4, which can reduce oxymorphone formation and raise oxycodone levels. Analgesia may change and opioid adverse effects may increase.
How serious is the interaction between Oxycodone and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and signs of opioid excess, titrating oxycodone to effect. Reduce the dose if sedation or respiratory depression occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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