Drug interactions
Oxycodone + Ticagrelor
Severity: Moderate
Oxycodone and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and can delay and reduce absorption of oral ticagrelor and its active metabolite, potentially lowering early platelet inhibition. This matters in acute coronary syndrome.
What this interaction means in plain words
Oxycodone and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Opioid-induced delay in gastric emptying and gut motility reduces oral ticagrelor absorption.
What to do
In acute coronary syndrome requiring opioids, consider a parenteral antiplatelet agent. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Oxycodone with Ticagrelor?
MediHelp rates the interaction as moderate. Oxycodone and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and can delay and reduce absorption of oral ticagrelor and its active metabolite, potentially lowering early platelet inhibition. This matters in acute coronary syndrome.
How serious is the interaction between Oxycodone and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome requiring opioids, consider a parenteral antiplatelet agent. Use the lowest effective opioid dose.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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