Drug interactions
Oxycodone + Vecuronium
Severity: Moderate
Oxycodone and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can add to the respiratory depression associated with neuromuscular blockers, and recovery from blockade may be slower. This matters mainly during and after anesthesia, when ventilation depends on adequate return of muscle function.
What this interaction means in plain words
Oxycodone and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Vecuronium belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from central opioid effects and peripheral neuromuscular blockade; direct potentiation of blockade is not well established.
What to do
Provide ventilatory support and monitor neuromuscular function with quantitative train-of-four until full recovery. Reduce opioid doses where possible after surgery and observe closely for residual weakness or hypoventilation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Vecuronium
Frequently asked questions
Can I take Oxycodone with Vecuronium?
MediHelp rates the interaction as moderate. Oxycodone and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can add to the respiratory depression associated with neuromuscular blockers, and recovery from blockade may be slower. This matters mainly during and after anesthesia, when ventilation depends on adequate return of muscle function.
How serious is the interaction between Oxycodone and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Provide ventilatory support and monitor neuromuscular function with quantitative train-of-four until full recovery. Reduce opioid doses where possible after surgery and observe closely for residual weakness or hypoventilation.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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