Drug interactions
Oxymorphone + Ozanimod
Severity: Moderate
Oxymorphone and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, so there is a theoretical risk of serotonergic or adrenergic reactions with opioids. Oxymorphone has little serotonergic activity, so the actual risk is likely low.
What this interaction means in plain words
Oxymorphone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite; clinical significance with oxymorphone is uncertain.
What to do
Monitor blood pressure and for signs of serotonin toxicity or agitation. Consider alternatives if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Oxymorphone with Ozanimod?
MediHelp rates the interaction as moderate. Oxymorphone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, so there is a theoretical risk of serotonergic or adrenergic reactions with opioids. Oxymorphone has little serotonergic activity, so the actual risk is likely low.
How serious is the interaction between Oxymorphone and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for signs of serotonin toxicity or agitation. Consider alternatives if symptoms appear.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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