Drug interactions
Oxymorphone + Pegvisomant
Severity: Moderate
Oxymorphone and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids have been reported to reduce the effectiveness of pegvisomant in acromegaly, with higher pegvisomant doses sometimes required. The mechanism is not established, and the evidence is limited.
What this interaction means in plain words
Oxymorphone and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Pegvisomant belongs to Endocrine.
Why it happens
Mechanism is not established.
What to do
Monitor serum IGF-I when starting or stopping oxymorphone and adjust the pegvisomant dose according to the response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Oxymorphone with Pegvisomant?
MediHelp rates the interaction as moderate. Oxymorphone and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids have been reported to reduce the effectiveness of pegvisomant in acromegaly, with higher pegvisomant doses sometimes required. The mechanism is not established, and the evidence is limited.
How serious is the interaction between Oxymorphone and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-I when starting or stopping oxymorphone and adjust the pegvisomant dose according to the response.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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