Drug interactions
Oxymorphone + Pregabalin
Severity: Major
Oxymorphone and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin adds to the sedative and respiratory depressant effects of opioids such as oxymorphone. Together they can cause profound drowsiness, slowed breathing and, in vulnerable patients, fatal respiratory depression.
What this interaction means in plain words
Oxymorphone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and the shortest duration of both drugs, starting low in opioid-naive patients. Monitor for sedation and respiratory depression, especially in the elderly, those with COPD or renal impairment, and after dose increases.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Oxymorphone with Pregabalin?
MediHelp rates the interaction as major. Oxymorphone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin adds to the sedative and respiratory depressant effects of opioids such as oxymorphone. Together they can cause profound drowsiness, slowed breathing and, in vulnerable patients, fatal respiratory depression.
How serious is the interaction between Oxymorphone and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and the shortest duration of both drugs, starting low in opioid-naive patients. Monitor for sedation and respiratory depression, especially in the elderly, those with COPD or renal impairment, and after dose increases.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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