Drug interactions
Oxymorphone + Sevoflurane
Severity: Major
Oxymorphone and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane combined with opioids produce additive CNS depression, hypotension and respiratory depression. Opioids reduce the anesthetic requirement, which is intentional but needs monitoring.
What this interaction means in plain words
Oxymorphone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and cardiorespiratory depression.
What to do
Use only with anesthesia-level monitoring and airway support, and titrate anesthetic and opioid doses to effect. Monitor for postoperative respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Oxymorphone with Sevoflurane?
MediHelp rates the interaction as major. Oxymorphone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Volatile anesthetics such as sevoflurane combined with opioids produce additive CNS depression, hypotension and respiratory depression. Opioids reduce the anesthetic requirement, which is intentional but needs monitoring.
How serious is the interaction between Oxymorphone and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with anesthesia-level monitoring and airway support, and titrate anesthetic and opioid doses to effect. Monitor for postoperative respiratory depression.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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