Drug interactions
Oxymorphone + Stiripentol
Severity: Moderate
Oxymorphone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and is used with clobazam and valproate, so adding an opioid increases sedation and respiratory depression risk. Stiripentol also inhibits several enzymes, but oxymorphone relies mainly on glucuronidation.
What this interaction means in plain words
Oxymorphone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Start oxymorphone at a low dose and monitor for excess sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Oxymorphone with Stiripentol?
MediHelp rates the interaction as moderate. Oxymorphone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and is used with clobazam and valproate, so adding an opioid increases sedation and respiratory depression risk. Stiripentol also inhibits several enzymes, but oxymorphone relies mainly on glucuronidation.
How serious is the interaction between Oxymorphone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oxymorphone at a low dose and monitor for excess sedation and respiratory depression.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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