Drug interactions
Oxytocin + Sevoflurane
Severity: Moderate
Oxytocin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval, and oxytocin has been associated with QT prolongation and hypotension or tachycardia when given as a bolus. During obstetric anesthesia, the combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Oxytocin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxytocin belongs to Endocrine; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation; oxytocin also causes hemodynamic changes that may increase the risk of arrhythmia.
What to do
Give oxytocin as a slow infusion rather than a bolus, and monitor the ECG and blood pressure. Correct electrolytes and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Oxytocin with Sevoflurane?
MediHelp rates the interaction as moderate. Oxytocin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval, and oxytocin has been associated with QT prolongation and hypotension or tachycardia when given as a bolus. During obstetric anesthesia, the combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Oxytocin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oxytocin as a slow infusion rather than a bolus, and monitor the ECG and blood pressure. Correct electrolytes and avoid other QT-prolonging drugs where possible.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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