Drug interactions
Ozanimod + Pneumococcal vaccine 13-valent
Severity: Minor
Ozanimod and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes, which may blunt the antibody response to inactivated vaccines such as the 13-valent pneumococcal conjugate vaccine. Protection after vaccination may therefore be lower than expected, though the clinical significance has not been well defined.
What this interaction means in plain words
Ozanimod and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ozanimod belongs to Central Nervous System; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Sphingosine-1-phosphate receptor modulation sequesters lymphocytes in lymphoid tissue, potentially reducing the vaccine immune response.
What to do
If possible, complete pneumococcal vaccination at least 2 weeks before starting ozanimod; if already on treatment, vaccinate as indicated and consider the response may be reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Ozanimod and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ozanimod reduces circulating lymphocytes, which may blunt the antibody response to inactivated vaccines such as the 13-valent pneumococcal conjugate vaccine. Protection after vaccination may therefore be lower than expected, though the clinical significance has not been well defined.
How serious is the interaction between Ozanimod and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, complete pneumococcal vaccination at least 2 weeks before starting ozanimod; if already on treatment, vaccinate as indicated and consider the response may be reduced.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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