Drug interactions
Ozanimod + Primaquine
Severity: Moderate
Ozanimod and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and the QT effect of primaquine may add to the arrhythmic risk. Clinical evidence for a significant interaction is limited.
What this interaction means in plain words
Ozanimod and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Possible additive cardiac effects: S1P-mediated bradycardia with QT prolongation from primaquine.
What to do
Check a baseline ECG and monitor heart rate and QTc during coadministration. Correct electrolytes and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Primaquine?
MediHelp rates the interaction as moderate. Ozanimod and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and the QT effect of primaquine may add to the arrhythmic risk. Clinical evidence for a significant interaction is limited.
How serious is the interaction between Ozanimod and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor heart rate and QTc during coadministration. Correct electrolytes and avoid other QT-prolonging drugs.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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