Drug interactions
Ozanimod + Propafenone
Severity: Moderate
Ozanimod and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and propafenone is a class 1C antiarrhythmic that slows conduction and can prolong QRS and QT intervals. Combined use may increase the risk of bradycardia, heart block and arrhythmia.
What this interaction means in plain words
Ozanimod and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on heart rate, AV conduction and cardiac repolarization.
What to do
Obtain a baseline ECG before starting ozanimod and seek cardiology advice in patients taking propafenone. Monitor heart rate and ECG during treatment initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Propafenone?
MediHelp rates the interaction as moderate. Ozanimod and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and propafenone is a class 1C antiarrhythmic that slows conduction and can prolong QRS and QT intervals. Combined use may increase the risk of bradycardia, heart block and arrhythmia.
How serious is the interaction between Ozanimod and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and seek cardiology advice in patients taking propafenone. Monitor heart rate and ECG during treatment initiation.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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