Drug interactions
Ozanimod + Quetiapine
Severity: Moderate
Ozanimod and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction on initiation, while quetiapine can prolong the QT interval. Bradycardia may increase the arrhythmic risk of QT-prolonging drugs.
What this interaction means in plain words
Ozanimod and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive bradycardic effect of S1P modulation and QT prolongation from quetiapine.
What to do
Obtain a baseline ECG and seek cardiology input before starting ozanimod in patients taking quetiapine. Monitor heart rate and QTc and keep electrolytes normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Quetiapine?
MediHelp rates the interaction as moderate. Ozanimod and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction on initiation, while quetiapine can prolong the QT interval. Bradycardia may increase the arrhythmic risk of QT-prolonging drugs.
How serious is the interaction between Ozanimod and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and seek cardiology input before starting ozanimod in patients taking quetiapine. Monitor heart rate and QTc and keep electrolytes normal.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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