Drug interactions
Ozanimod + Quinidine
Severity: Major
Ozanimod and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine prolongs the QT interval and can cause torsades de pointes, while ozanimod slows heart rate on initiation. Bradycardia increases vulnerability to QT-related arrhythmias, so the combination raises proarrhythmic risk.
What this interaction means in plain words
Ozanimod and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic effects of QT prolongation (quinidine) and sphingosine-1-phosphate receptor-mediated heart rate slowing (ozanimod).
What to do
Avoid starting ozanimod in patients taking quinidine unless a cardiologist has reviewed the risk; if used, obtain a baseline ECG and monitor ECG and electrolytes (K, Mg).
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Quinidine?
MediHelp rates the interaction as major. Ozanimod and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine prolongs the QT interval and can cause torsades de pointes, while ozanimod slows heart rate on initiation. Bradycardia increases vulnerability to QT-related arrhythmias, so the combination raises proarrhythmic risk.
How serious is the interaction between Ozanimod and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients taking quinidine unless a cardiologist has reviewed the risk; if used, obtain a baseline ECG and monitor ECG and electrolytes (K, Mg).
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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